Hundreds of Egyptians filled Tahrir Square in Cairo on Friday to demand the resignation of Fattah al – Sisi, who took power in 2014.
The protests which are among the first against al Sisi spread to other parts of Egypt in a show of unity against a corrupt government according to reports.
Egyptians accuse Sisi of wasting millions of money on luxury residences and hotels at the expense of millions of Egyptians living in poverty.
Late on Friday, “Sisi out” and “The people want to overthrow the government topped Egypt’s Twitter trending list.
The main protest was at Tahrir Square, the site of the 2011 Egyptian Revolution that saw the fall of Hosni Mubarak’s regime.
Demonstrations were also reported in Egypt’s second largest city Alexandria and in Suez according to Al Jazeera.
In 2013, Mr Sisi led the military’s overthrow of Egypt’s first democratically elected president, Mohammed Morsi, following protests against his rule.
Since then, he has overseen what human rights groups say is an unprecedented crackdown on dissent that has led to the detention of tens of thousands of people.
President Sisi has dismissed the allegations as “lies and slander”.